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Functional study of ABCG2 intracellular loops and human ABCG2 and ABCB1 modul...
Resistance to chemotherapy is partly due to efflux pumps expressed in the plasma membrane which prevent the accumulation of anticancer drugs in the tumour cells. Three... -
Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting ...
International audience -
Role of the mesenchymal niche in SP phenotype regulation of human hematopoiet...
Hematopoiesis is a finely tuned process to allow its long-term efficiency and its adaptation to various physiological and pathological stresses. Hematopoietic stem... -
Identification and mechanism of selective modulators of the ABCG2 transporter...
ABCB1, ABCC1 and ABCG2 are the 3 human ABC transporters mainly involved in chemoresistance of some cancer cells. Two strategies may eradicate such a resistance: 1) by...
