-
Activation of the N F-kB pathway by the Tax proteins of the HTLV viruses : Ro...
Human T cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), a CD4+ T-cell malignancy, Constitutive activation of the NF-KB... -
Relation between DDB2 protein and transcription factor NF-kB : consequences o...
The Damaged DNA-Binding 2 protein (DDB2) is known to play a role in repair of UV-induced DNA damages. However, the laboratory has shown that this protein is... -
ROLE OF THE PSEUDOMONAS AERUGINOSA EXOENZYME S IN THE BACTERIAL VIRULENCE : F...
The type III exoenzyme S toxin of Pseudomonas aeruginosa possesses a GAP domain (GTPase Activating Protein) (ExosGAP) inhibiting the Rho GTPases (Rho, Rac and Cdc42)... -
High Resolution study of NF-kB - DNA Interactions
In this thesis we have attempted to study four basic aspects of DNA-protein interactions: Affinity, specificity, accessibility and kinetics. With NF-kB as our model... -
Deregulation of alternative splicing during HTLV-1 infection : role of Tax
Reprogramming cellular gene transcription sustains HTLV-1 viral persistence that ultimately leads to the development of adult T-cell leukemia/lymphoma (ATLL). We...
